Which medications in the drug class Antiemetic Agents are used in the treatment of Childhood Migraine Variants?

Updated: Nov 19, 2019
  • Author: Wendy G Mitchell, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP, FANA  more...
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Antiemetic Agents

Antiemetics may be administered (orally, rectally, or intravenously [IV]) if nausea or vomiting is prominent.

Promethazine HCl (Phenergan, Phenadoz, Promethegan)

Promethazine is an antiemetic and sedative that is available in oral, rectal, and parenteral preparations. It blocks postsynaptic mesolimbic dopaminergic receptors in the brain and reduces stimuli to the brainstem reticular system.

Metoclopramide (Reglan, Metozolv)

Metoclopramide blocks dopamine receptors in the chemoreceptor trigger zone of the central nervous system (CNS). It is indicated for migraine-associated nausea.

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