Which medications in the drug class Calcium Channel Blockers are used in the treatment of Childhood Migraine Variants?

Updated: Nov 19, 2019
  • Author: Wendy G Mitchell, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP, FANA  more...
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Calcium Channel Blockers

Migraine prophylaxis has been reported with various calcium channel blockers, including verapamil, nifedipine, and others. The calcium channel blocker with the highest evidence of efficacy is flunarizine, which is not available in the United States. Results are not entirely predictable, and dosage must be individualized. Some patients experience exacerbation of migraine with these agents.

Verapamil (Calan, Calan SR, Covera-HS, Verelan)

Verapamil relaxes smooth muscles and increases oxygen delivery during vasospasms. It is used in children for migraine with aura and basilar migraine. Verapamil has not been FDA-approved for use in migraine.

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