Which medications in the drug class Metabolic Support are used in the treatment of Childhood Migraine Variants?

Updated: Nov 19, 2019
  • Author: Wendy G Mitchell, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP, FANA  more...
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Answer

Metabolic Support

Metabolic support to prevent catabolic state is indicated in migrainelike episodes caused by suspected mitochondrial cytopathies. IV glucose and, occasionally, carnitine supplementation may be useful.

Dextrose

Dextrose is administered with the goal of preventing dehydration and a catabolic state in mitochondrial cytopathies.

Levocarnitine (Carnitor)

Levocarnitine is a vitaminlike substance that is necessary for transport of fatty acids into mitochondria; it is a cofactor in mitochondrial energy production. Levocarnitine can be deficient in organic acidurias or mitochondrial dysfunction and can be depleted by the administration of valproic acid. Supplementation with levocarnitine may be helpful in mitochondrial cytopathies to prevent severe metabolic collapse and encephalopathy. Supplementation may be useful in cyclic vomiting or atypical migraine syndromes caused by mitochondrial dysfunction.


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