Which medications in the drug class Benzodiazepines are used in the treatment of Tuberous Sclerosis?

Updated: Aug 21, 2018
  • Author: David Neal Franz, MD; Chief Editor: Amy Kao, MD  more...
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Answer

Benzodiazepines

By binding to specific receptor sites, these agents appear to potentiate the effects of GABA and facilitate inhibitory GABA neurotransmission and other inhibitory transmitters. Nitrazepam is not approved by US FDA but is available in many countries worldwide and may be more effective and better tolerated in specific individuals.

Clonazepam (Klonopin)

Considered first- or second-line AED therapy depending on seizure type. Adverse effects and development of tolerance limit usefulness over time. 

Clobazam (ONFI)

Clobazam was approved by the FDA in 2011 for adjunctive therapy for seizures in patients age 2 and older with Lennox-Gastaut syndrome. It is a 1,5-benzodiazepine, and seems to differ from traditional 1,4-benzodiazepines. Some studies suggest lower neurotoxicity and greater efficacy.


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