What is the role of MRI with DTI in the workup of Sturge-Weber syndrome (SWS)?

Updated: Dec 26, 2018
  • Author: Masanori Takeoka, MD; Chief Editor: George I Jallo, MD  more...
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Answer

Sivaswamy et al reported diffusion tensor imaging (DTI) abnormalities in the corticospinal tract of the affected hemisphere, which were seen before severe motor deficits developed. [70] In this study, the authors found lower fraction anisotropy (FA) values and higher ADC values of the cortical spinal tract in the affected hemisphere in 16 children with SWS (aged 1.5-12.3 y).

Interestingly, Moritani et al reported increased FA and decreased ADC in the subcortical white matter adjacent to the LAs in a term neonate aged 7 days with SWS. [71] As there are such varied findings on DTI and ADC, further studies are necessary to clarify the nature of DTI and ADC changes in SWS. It is likely that these changes are influenced by multiple factors, such as age and the stage of SWS.


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