What is the role of MR spectroscopy and diffusion-weighted MRI in the workup of Sturge-Weber syndrome (SWS)?

Updated: Dec 26, 2018
  • Author: Masanori Takeoka, MD; Chief Editor: George I Jallo, MD  more...
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Answer

MR spectroscopy has shown increased choline but no reduction in the neuronal marker N- acetyl aspartate (NAA) in SWS, although in other reports, MR spectroscopy has shown decreased NAA. [66] Cakirer et al showed decreased NAA and increased choline in a patient with SWS, while the abnormal area also showed increased apparent diffusion coefficient (ADC) on diffusion-weighted MRI. [67, 68]

Regarding the MR spectroscopy findings in these studies, the decreased NAA was considered to represent neuronal loss, and the elevated choline was believed to demonstrate a lack of normal development.


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