How are lipid abnormalities resolved in patients with type 1 diabetes mellitus (DM)?

Updated: Jul 28, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Answer

Persistent lipid abnormalities remain in patients with diabetes, despite evidence supporting the benefits of lipid-modifying drugs. Up-titration of the statin dose and addition of other lipid-modifying agents are needed. [152] Although metformin is used principally in type 2 DM because of its lipid-lowering effect, a placebo-controlled study by Lund et al found that metformin (1000 mg orally twice daily) significantly reduced total cholesterol and low-density lipoprotein (LDL) cholesterol in patients with type 1 DM. [153]


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