What is the sibling risk for type 1 diabetes mellitus (DM)?

Updated: Jun 27, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Answer

Although the genetic aspect of type 1 DM is complex, with multiple genes involved, there is a high sibling relative risk. [18] Whereas dizygotic twins have a 5-6% concordance rate for type 1 DM, [19] monozygotic twins will share the diagnosis more than 50% of the time by the age of 40 years. [20]


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