What is the role of cerebrospinal fluid analysis in the workup of neonatal seizures?

Updated: Jul 31, 2019
  • Author: Raj D Sheth, MD; Chief Editor: Stephen L Nelson, Jr, MD, PhD, FAACPDM, FAAN, FAAP  more...
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Answer

This should include tests checking for the following:

  • Pleocytosis

  • Xanthochromia - Suggestive of blood breakdown products, particularly if jaundice is not present

  • Lactic acid and pyruvate - For evidence of mitochondrial cytopathies

  • Herpes virus - Using a polymerase chain reaction (PCR) assay

  • Amino acids - To detect nonketotic hyperglycinemia

  • Glucose concentration - Low glucose concentration is suggestive of bacterial meningitis

In the absence of bacterial meningitis, persistently low CSF glucose concentrations may suggest a glucose transporter defect.


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