Which medications in the drug class Benzodiazepines are used in the treatment of Lennox-Gastaut Syndrome?

Updated: Nov 09, 2018
  • Author: Koshi A Cherian, MD; Chief Editor: Amy Kao, MD  more...
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Answer

Benzodiazepines

By binding to specific receptor-sites, these agents appear to potentiate the effects of gamma-aminobutyrate (GABA) and facilitate inhibitory GABA neurotransmission and other inhibitory transmitters.

Clonazepam (Klonopin)

Clonazepam is considered an effective first-line AED therapy for seizures associated with LGS. Adverse effects and development of tolerance limit usefulness over time; dosing on an every-other-day schedule or alternating 2 benzodiazepines daily may slow development of tolerance. The benzodiazepine nitrazepam (Mogadon) is not approved by FDA but is available in many countries. The combination of valproic acid and a benzodiazepine may be better than either drug alone.

Clobazam (ONFI)

1,5-benzodiazepine that possesses potent anticonvulsant properties. Exact mechanism of action is not fully understood; thought to potentiate GABAergic neurotransmission resulting from binding to GABA-A receptor. The active metabolite, N-demethylclobazam, is largely responsible for its long duration of action. It is indicated for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients older than 2 years.


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