What is the role of vagus nerve stimulation in the treatment of Lennox-Gastaut syndrome (LGS)?

Updated: Nov 09, 2018
  • Author: Koshi A Cherian, MD; Chief Editor: Amy Kao, MD  more...
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Answer

Vagus nerve stimulation by means of a surgically implanted programmable device is approved by the FDA as an adjunctive treatment for refractory partial-onset seizures in adults and adolescents older than 12 years. In 3 published small studies, approximately three fourths of patients with LGS experienced greater than 50% reduction in seizure frequency with a follow-up period as long as 5 years. [35]  

A meta-analysis determined that corpus callosotomy has better outcomes than vagus nerve stimulation for atonic seizures, but that vagus stimulation has comparable benefit to corpus callosotomy for all other seizure types. [36]


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