What is the role of corpus callosotomy in the treatment of Lennox-Gastaut syndrome (LGS)?

Updated: Nov 09, 2018
  • Author: Koshi A Cherian, MD; Chief Editor: Amy Kao, MD  more...
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Answer

Corpus callosotomy is effective in reducing drop attacks but is typically not helpful for other seizure types. It is considered palliative rather than curative. Seizure freedom following corpus callosotomy is rare but can occur.

A 2006 study showed a greater than 90% seizure reduction in 52 of 76 patients with LGS who underwent an extended, one-stage, callosal section (splenium intact); 7 of the 76 patients were seizure free. [34] The mean follow-up time was 4.7 years. The seizure types most responsive to surgery were atonic and atypical absence.


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