What is the role of felbamate (Felbatol) in the treatment of Lennox-Gastaut syndrome (LGS)?

Updated: Nov 09, 2018
  • Author: Koshi A Cherian, MD; Chief Editor: Amy Kao, MD  more...
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Answer

Felbamate (Felbatol) was found to be safe and effective in patients with LGS in a randomized, double-blind, placebo-controlled adjunctive therapy trial, and 12-month follow-up in patients who completed controlled part of study confirmed long-term efficacy. [21] Despite the efficacy of felbamate, the significant risk of idiosyncratic reactions associated with its use make it a third-line or fourth-line drug for LGS.


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