What is the role of lamotrigine (Lamictal) in the treatment of Lennox-Gastaut syndrome (LGS)?

Updated: Nov 09, 2018
  • Author: Koshi A Cherian, MD; Chief Editor: Amy Kao, MD  more...
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Answer

The efficacy of lamotrigine (Lamictal) as adjunctive therapy against seizures associated with LGS was demonstrated in 2 controlled trials and multiple open-label studies. This agent is valuable for patients with LGS, despite its risk of idiosyncratic dermatologic reactions, and its use should be considered as soon as diagnosis of LGS is made. Proper attention to concomitant medications, low starting dose, and very slow titration can minimize the risk of dermatologic reactions.


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