What is the role of medications in the treatment of Lennox-Gastaut syndrome (LGS)?

Updated: Nov 09, 2018
  • Author: Koshi A Cherian, MD; Chief Editor: Amy Kao, MD  more...
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The medical treatment options for patients with LGS can be divided into the following 3 major groups:

  • First-line treatments based on clinical experience or conventional wisdom (eg, valproic acid, benzodiazepines [specifically clonazepam, nitrazepam, clobazam [12, 13, 14] ])

  • Treatments suspected to be effective on the basis of open-label uncontrolled studies (eg, vigabatrin, [15] zonisamide [16] )

  • Treatments proven effective by double-blind placebo-controlled studies (eg, lamotrigine, [17] topiramate, [18, 19, 20] felbamate [21] , rufinamide [22, 23, 24] , clobazam [25] , cannabidiol [26, 27] )

The ketogenic diet may be useful in patients with LGS refractory to medical treatment. Surgical options for LGS include corpus callostomy, vagus nerve stimulation, and focal cortical resection. [28]

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