What causes Lennox-Gastaut syndrome (LGS)?

Updated: Nov 09, 2018
  • Author: Koshi A Cherian, MD; Chief Editor: Amy Kao, MD  more...
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Population-based studies have found that 70-78% of patients with LGS have symptomatic LGS. Underlying pathologies in these cases may include the following:

  • Encephalitis and/or meningitis

  • Tuberous sclerosis

  • Brain malformations (eg, cortical dysplasias)

  • Hypoxia-ischemia injury

  • Frontal lobe lesions

  • Traumatic brain injury

There is a history of infantile spasms in 9-39% of LGS patients.

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