Which medications are used in the treatment of Lennox-Gastaut syndrome (LGS)?

Updated: Nov 09, 2018
  • Author: Koshi A Cherian, MD; Chief Editor: Amy Kao, MD  more...
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Medical treatment options may be divided into the following 3 major groups:

  • First-line treatments based on clinical experience or conventional wisdom – valproic acid, benzodiazepines (specifically, clonazepam, nitrazepam, and clobazam; there have been occasional reports of worsening of tonic seizures by benzodiazepines)

  • Treatments suspected to be effective on the basis of open-label uncontrolled studies – vigabatrin, zonisamide

  • Treatments proven effective by double-blind placebo-controlled studies – lamotrigine, topiramate, felbamate, rufinamide, clobazam, cannabidiol

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