Which medications in the drug class Vasopressin-Related Hormones are used in the treatment of Diabetes Insipidus?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Vasopressin-Related Hormones

In patients with central DI, replacement of endogenous ADH with exogenous hormones prevents complications of DI and reduces morbidity.

Desmopressin (DDAVP, Stimate)

Desmopressin is a synthetic analogue of ADH with potent antidiuretic activity but no vasopressor activity.

Vasopressin (Pitressin)

Vasopressin has vasopressor and ADH activity. It increases water resorption at collecting ducts (ADH effect). At high doses, it also promotes smooth muscle contraction throughout the vascular bed of renal tubular epithelium (vasopressor effects). However, vasoconstriction is also increased in splanchnic, portal, coronary, cerebral, peripheral, pulmonary, and intrahepatic vessels.

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