Which medications in the drug class Nonsteroidal Anti-inflammatory Agents (NSAIDs) are used in the treatment of Diabetes Insipidus?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Answer

Nonsteroidal Anti-inflammatory Agents (NSAIDs)

The mechanism of action of NSAIDs is not known, but these agents may act by inhibiting prostaglandin synthesis.

Indomethacin (Indocin)

Inhibition of prostaglandin synthesis reduces the delivery of solute to distal tubules, reducing urine volume and increasing urine osmolality. Indomethacin is usually used in nephrogenic DI.

Ibuprofen (Caldolor, Advil, Motrin)

Inhibition of prostaglandin synthesis reduces the delivery of solute to distal tubules, reducing urine volume and increasing urine osmolality. Ibuprofen is usually used in nephrogenic DI.

Naproxen (Naprosyn, Naprelan, Aleve, Anaprox)

Diclofenac (Voltaren, Cataflam XR, Zipsor, Cambia)

Ketoprofen

Inhibition of prostaglandin synthesis reduces the delivery of solute to distal tubules, reducing urine volume and increasing urine osmolality.


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