Which medications in the drug class Diuretics, Potassium-Sparing are used in the treatment of Diabetes Insipidus?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Diuretics, Potassium-Sparing

Diuretics may reduce flow to the ADH-sensitive distal nephron.


Amiloride is a potassium-sparing diuretic. Thus, the risk of hypokalemia is decreased when amiloride is used in combination with hydrochlorothiazide. In addition, the 2 agents are synergistic with respect to antidiuresis.

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