What causes misleading water deprivation test results in the workup of diabetes insipidus (DI)?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Answer

Water deprivation test results may be misleading in patient with chronic primary polydipsia, who may experience partial washout of the medullary interstitial gradient and downregulation of ADH release. This would resemble nephrogenic DI, with an inability to concentrate urine. The combination of a plasma ADH assay with water deprivation testing can lead to greater accuracy in differentiating the different forms of DI from each other and from primary polydipsia. [32]


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