What are symptoms and signs of anterior pituitary dysfunction in diabetes insipidus (DI)?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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If the condition that caused DI also damaged the anterior pituitary or hypothalamic centers that produce releasing factors, patients may present with other symptoms and signs of anterior pituitary dysfunction. These would include excessive fatigue, diminished libido or erectile dysfunction, headache, dry skin, and hair loss.

A study by Masri-Iraqi et al suggested that anterior pituitary dysfunction occurs in the majority of adults with central DI. The investigators found that in 73% of the study’s subjects, which consisted of 70 adults with central DI, one or more anterior pituitary axes were affected. [28]

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