Does targeted temperature management (TTM) of cardiac arrest increase the risk of developing central diabetes insipidus (DI)?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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A study by Lee et al found that 12% of cardiac arrest survivors treated with targeted temperature management (TTM) developed central DI, with these patients demonstrating poor neurologic outcomes and high mortality rates. The study involved 385 patients, 45 of whom were confirmed to have central DI. Multivariate analysis indicated that in cardiac arrest survivors treated with TTM, independent risk factors for central DI include younger age, nonshockable rhythm, long downtime, and asphyxial cardiac arrest. [19]

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