What are the causes of central diabetes insipidus (DI)?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Central DI has many possible causes. According to the literature, the principal causes of central DI and their oft-cited approximate frequencies are as follows:

  • Idiopathic - 30%

  • Malignant or benign tumors of the brain or pituitary - 25%

  • Cranial surgery - 20%

  • Head trauma - 16% [7]

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