What is the role of arginine vasopressin (AVP) in the pathogenesis of diabetes insipidus (DI)?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Answer

AVP is the primary determinant of free water excretion in the body. Its main target is the kidney, where it acts by altering the water permeability of the cortical and medullary collecting tubules. Water is reabsorbed by osmotic equilibration with the hypertonic interstitium and returned to the systemic circulation. The actions of AVP are mediated through at least 2 receptors, as follows [5, 6] :

  • V1 - Mediates vasoconstriction, enhancement of corticotrophin release, and renal prostaglandin synthesis

  • V2 - Mediates the antidiuretic response


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