What are gestational diabetes insipidus (DI) and primary polydipsia?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Two other forms of DI are gestational DI and primary polydipsia. Both are caused by deficiencies in AVP, but the deficiencies do not result from a defect in the neurohypophysis or kidneys. Gestational DI results from degradation of vasopressin by a placental vasopressinase. Primary polydipsia (dipsogenic DI) results from a primary defect in osmoregulation of thirst. The exact location of the lesion is not known, but structural lesions may exist, as dipsogenic DI has been reported in tuberculous meningitis, multiple sclerosis, and neurosarcoidosis.

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