How is nephrogenic diabetes insipidus (DI) characterized?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Nephrogenic DI is characterized by a decrease in the ability to concentrate urine because of resistance to ADH action in the kidney. [1] Nephrogenic DI can be observed in chronic renal insufficiency, lithium toxicity, hypercalcemia, hypokalemia, glucosuria, and tubulointerstitial disease. (See Etiology, Presentation, and Workup.)

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