What are pharmacologic therapies in the treatment of diabetes insipidus (DI)?

Updated: Mar 18, 2020
  • Author: Romesh Khardori, MD, PhD, FACP; Chief Editor: George T Griffing, MD  more...
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Pharmacologic therapeutic options include the following:

  • Desmopressin (drug of choice for central DI [3, 4] )

  • Synthetic vasopressin

  • Chlorpropamide

  • Carbamazepine (rarely used; employed only when all other measures prove unsatisfactory)

  • Clofibrate (no longer on the US market)

  • Thiazides

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin (may be used in nephrogenic DI, but only when no better options exist)

See Treatment and Medication for more detail.

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