What is the role of selenium in the pathophysiology of mercury toxicity?

Updated: Nov 05, 2018
  • Author: David A Olson, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Answer

Furthermore, methylmercury may sequester the element selenium and thereby disrupt cellular biochemical pathways that use selenium as an enzymatic cofactor. Substantial evidence suggests that supplementing selenium ameliorates or even reverses mercury toxicity in laboratory animals. [15]


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