Which medications are used in the treatment of methanol toxicity?

Updated: Nov 05, 2018
  • Author: Kalyani Korabathina, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Ethanol and fomepizole can be administered to delay methanol metabolism until the methanol is eliminated from the patient’s system (either naturally or with dialysis). These antidotes work via competitive inhibition; ethanol and fomepizole are metabolized by ADH, just as methanol is, but the enzyme has a higher affinity for both antidotes than it does for methanol. For example, the affinity of ADH for ethanol is 10-20 times greater than it is for methanol. The use of fomepizole is limited because of its high cost and lack of availability. [10]

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