What is the time course of methanol toxicity?

Updated: Nov 05, 2018
  • Author: Kalyani Korabathina, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Answer

A careful history should be taken in high-risk patients who report typical symptoms of methanol poisoning.

Time course

Initial symptoms generally occur 12-24 hours after ingestion. The interval between ingestion and the appearance of symptoms correlates to the volume of methanol ingested and the amount of ethanol concomitantly ingested; competitive inhibition exists between the 2 compounds. [10]

Methanol blood levels peak at 30-90 minutes following ingestion and often do not correlate to the time to symptom appearance.


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