What is the role of a provocative chelation test in the workup of lead toxicity?

Updated: Jan 16, 2020
  • Author: Pranay Kathuria, MD, FACP, FASN, FNKF; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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A provocative chelation test may provide additional information (eg, total-body burden). It should not be done in acute lead poisoning because of the potential of precipitating or worsening encephalopathy. Urine is collected after administering a dose of a chelation agent. Edetate (EDTA) calcium disodium (CaNa2 EDTA) is the most commonly used chelator for this test.

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