What is central pontine myelinolysis (CPM)?

Updated: Oct 09, 2017
  • Author: Christopher Luzzio, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
  • Print
Answer

Answer

Adams et al described central pontine myelinolysis (CPM) as a unique clinical entity. They published their findings in 1958, observing that patients who suffered from alcoholism or malnutrition developed spastic quadriplegia, pseudobulbar palsy, and varying degrees of encephalopathy or coma from acute, noninflammatory demyelination that centered within the basis pontis. [1]

Physicians currently recognize that central pontine myelinolysis occurs inconsistently as a complication of severe and prolonged hyponatremia, particularly when corrected too rapidly. [2] Standard of care requires judicious treatment of electrolyte disturbances to reduce the incidence of osmotic myelinolysis. [3]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!