What is the mortality and morbidity associated with multifocal motor neuropathy (MMN) with conduction block?

Updated: Nov 12, 2018
  • Author: Sasa Zivkovic, MD, PhD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Dexterity and walking ability are commonly affected to some extent, but most patients are able to maintain autonomy with indoor and outdoor activities. [11] Most patients maintain productive lives despite ongoing symptoms, and up to 94% remain employed. [1] However, gradual progression of symptoms may also lead to significant disability. [12]

Fatal outcomes have been reported only rarely, and at least some case reports describe patients with other entities, including motor neuron disease.

Rarely, multifocal motor neuropathy may be associated with a B-cell lymphoma producing monoclonal antibodies against GM1 and GD1b myelin glycolipids.


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