Which medications in the drug class Antidepressants are used in the treatment of Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies?

Updated: May 22, 2018
  • Author: Timothy C Parsons, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Antidepressants

These drugs increase the synaptic concentration of serotonin and/or norepinephrine in CNS by inhibiting their reuptake at the presynaptic neuronal membrane. These mechanisms may play a role in the analgesic effects of these medications.

Nortriptyline (Pamelor, Aventyl HCl)

Has demonstrated effectiveness in treatment of pain.

Amitriptyline (Elavil)

Has demonstrated effectiveness in treatment of pain.


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