Which medications in the drug class Anticonvulsants are used in the treatment of Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies?

Updated: May 22, 2018
  • Author: Timothy C Parsons, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Anticonvulsants

These medications reduce neuronal excitability and prevent neuronal discharges associated with pain sensation.

Carbamazepine (Tegretol)

A sodium channel blocker that typically provides substantial or complete relief of pain in 80% of individuals with both idiopathic and MS-associated TN within 24-48 h. Adverse effect profile for older patients is more onerous than with newer anticonvulsants, thereby limiting usefulness in this group. As more published data on long-term efficacy of agents such as lamotrigine and gabapentin become available, these medications may soon become drugs of choice.

Gabapentin (Neurontin)

Uncontrolled studies have indicated possible effectiveness in patients whose pain has become refractory to carbamazepine. Often is tolerated better than carbamazepine by elderly patients. No placebo-controlled studies have been published.


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