In which age groups is the onset of Charcot-Marie-Tooth (CMT) disease most common?

Updated: May 22, 2018
  • Author: Timothy C Parsons, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Onset is usually in childhood. Thomas and colleagues found that 75% of patients with CMT1A developed clinical evidence of disease before age 10, and 85% before age 20. [65] Some patients experience very slow progression of mild, lifelong symptoms, and may seek medical attention only late in life.

There are patients and families in which CMT has a late onset, as late as the fifth or sixth decade in some MPZ mutations, and even as late as the seventh decade in CMT2. [41, 66]


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