Which conditions are associated with sporadic inclusion body myositis (s-IBM)?

Updated: Jun 08, 2018
  • Author: Michael P Collins, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Autoimmune and other conditions have been reported in patients, but the relationship to s-IBM is unclear. These included idiopathic interstitial pneumonitis, psoriasis, primary biliary cirrhosis, [77] sarcoidosis, Sjogren syndrome, [78] celiac sprue, and idiopathic thrombocytopenic purpura, [79] macrophagic myofasciitis, [80] systemic lupus erythematosus, [81, 82, 83] and dermatomyositis.

Creutzfeldt-Jakob disease has been described in association with s-IBM. [84]

Cancer is an uncommonly associated condition. In the series by Lotz et al, 2 female patients were diagnosed as having cancer (breast and uterus) within a short period after diagnosis of s-IBM. [69] Arnardottir et al reported a case in association with chronic T-cell lymphocytic leukemia. [85] No established relationship of cancer to s-IBM exists.


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