Which physical findings are characteristic of Kennedy disease (KD)?

Updated: Sep 30, 2019
  • Author: Paul E Barkhaus, MD, FAAN, FAANEM; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Gynecomastia is probably the most common nonneurologic finding on examination, but it is not a criterion for diagnosis (see image below).

Prominence of breast tissue consistent with gyneco Prominence of breast tissue consistent with gynecomastia in Kennedy disease.

Testicular atrophy, oligospermia and/or azoospermia, and erectile dysfunction may be present and typically occur in advanced cases.

In a clinical study, Sinclair et al found that men with KD may have a reduced risk of androgenetic alopecia compared with a cohort of white males of European descent without KD. [57]

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