What is the role of IV immunoglobulin in the treatment of stiff person syndrome?

Updated: Jun 14, 2018
  • Author: Nancy Theresa Rodgers-Neame, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Intravenous immunoglobulin

  • Intravenous immunoglobulin (IVIG) has also been used in the inpatient setting for the treatment of stiff person syndrome. The usual dose is 2 g/kg, administered over 2-5 days.

  • The length of the series is variable and dependent upon patient response. Treatment may extend past the inpatient period. [26] (Documentation of patient response is usually necessary for ongoing reimbursement by third party payers.)

  • Remember that IVIG is contraindicated in patients with IgA deficiency because of increased anaphylaxis in these patients.

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