How is IV immune globulin (IVIg) administered in the treatment of myasthenia gravis (MG)?

Updated: Aug 27, 2018
  • Author: Abbas Jowkar, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

IVIg is given as 400 mg/kg daily for 5 days (2 g/kg total).

Onset of action: 1-2 weeks with maximal effect: 1-3 weeks. 

Benefit can last for 3-5 weeks.

The effect of IVIg variable and slower in onset when compared to PLEX.

The dose is spreading over more days in patients with renal disease (Cr >1.4), diabetes mellitus, congestive heart failure, and in elderly.


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