What are the rituximab regimens used in the treatment of myasthenia gravis (MG)?

Updated: Aug 27, 2018
  • Author: Abbas Jowkar, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Rituximab regimens

Dosage regimen 1:

  • Rituximab 1 gm IV on day 1 and day 14
  • Further rituximab doses depend on whether CD19 count has returned to normal (usually at 6 months)
  • Rituximab 1 gm IV once at 6 months, if indicated

Dosage regimen 2:

  • Rituximab 375/m2 IV every 12 weeks for 48 weeks
  • Prednisone 60 mg daily until minimal manifestation state, then taper to 10 mg every 4 weeks

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