What is the role of anti-agrin antibodies in the evaluation of myasthenia gravis (MG)?

Updated: Aug 27, 2018
  • Author: Abbas Jowkar, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

About 80–90% of MG patients have detectable serum antibodies against AChRs with 40–70% of the remaining patients being positive for anti-MuSK antibodies and 2–50% for anti-LRP4 antibodies. This would leave approximately 2–5% of the MG patients triple seronegative, i.e., without detectable antibodies against any known autoantigen (AChR, MuSK or LRP4) at the NMJ.The presence of agrin antibodies in ‘triple seronegative’ patients with MG suggests that agrin may be a novel antigen in some triple seronegative MG patients. [51]


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