What is the significance of finding binding anti-acetylcholine receptor (AChR) ab in the evaluation of myasthenia gravis (MG)?

Updated: Aug 27, 2018
  • Author: Abbas Jowkar, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Sensitivity 88%–93% for generalized MG, and 50%–71% for ocular MG. False positives are rare and may be seen in thymoma without MG, Lambert-Eaton Mysthenic Syndrome (LEMS), graft-versus-host-disease (GVHD), autoimmune liver disease, small cell cancer, rheumatoid arthritis treated with d-penicillamine, and motor neuron disease. There is essentially an identical phenotype in patient with and without anti-AChR-ab (binding). [42]


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