What is the role of synaptic space in myasthenia gravis (MG)?

Updated: Aug 27, 2018
  • Author: Abbas Jowkar, MD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Located between the presynaptic region and the post-synaptic muscle membrane lies the synaptic left, which is 50–75 nm wide. It comprises the primary cleft and a number of secondary clefts (subneural clefts). The synaptic cleft is bound laterally by a basement membrane. The primary synaptic cleft has AChR concentrated at the crests of postsynaptic folds opposite the presynaptic active zones. Secondary synaptic clefts (subnerual clefts) are also a significant part of the post-synpatic membrane and located in its depth are present voltage-gated sodium channels.


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