Which clinical history findings are characteristic of autosomal-dominant limb-girdle muscular dystrophy 1F (LGMD1F)

Updated: Aug 15, 2019
  • Author: Monica Saini, MD, MBBS, MRCP(UK); Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
  • Print
Answer

LGMD1F (LGMDD2 TNPO3; 7q32)

One large family has been described. [49]

Onset is from the first year of life to the mid-50s.

Proximal weakness is noted early, with distal weakness as a late finding. Scapular winging may be noted.

Patients with a young onset may have rapid progression and require use of a wheelchair by their 20s–30s. They may also have facial and respiratory weakness and/or spinal deformity.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!