What are the signs and symptoms of limb-girdle muscular dystrophy (LGMD)?

Updated: Aug 15, 2019
  • Author: Monica Saini, MD, MBBS, MRCP(UK); Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Most patients present with a history of progressive, symmetric, proximal muscle weakness that starts in childhood to young adulthood. Pelvic muscle weakness is most often the first symptom. Other features may include the following:

  • Asymmetric or distal weakness (rare)

  • Respiratory failure

  • Cardiomyopathy, cardiac arrhythmias

  • Scapular winging

  • Calf hypertrophy

  • Contractures

See Clinical Presentation for more detail.


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