How is multifocal motor neuropathy treated?

Updated: Feb 20, 2018
  • Author: Sridharan Ramaratnam, MD, MBBS; Chief Editor: Helmi L Lutsep, MD  more...
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IV immunoglobulins are effective and commonly used for treating patients with multifocal motor neuropathy.

Either high-dose cyclophosphamide or monthly plasma exchange followed by pulse IV cyclophosphamide has been found effective in patients who do not respond to IV immunoglobulins. These patients do not respond to prednisone or plasmapheresis alone.

Whether the presence of anti-GM1 antibody or its titer has any bearing on the response to therapy is controversial.

Inclusion body myositis does not respond well to immunosuppressive medication.

Immunosuppressive treatment with corticosteroids may benefit focal myositis and sarcoid myopathy.

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