How is postpolio progressive muscular atrophy (PPMA) differentiated from amyotrophic lateral sclerosis (ALS)?

Updated: Feb 20, 2018
  • Author: Sridharan Ramaratnam, MD, MBBS; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

Features that distinguish PPMA from ALS

  • Age of onset of PPMA is earlier than that of ALS.

  • Females are affected with PPMA more often than ALS.

  • Motor involvement is usually focal or multifocal and asymmetric.

  • The frequency and distribution of fasciculations are sparse.

  • Bulbar and respiratory involvement are absent, except in survivors of bulbar cases.

  • Corticospinal tract signs are absent.

  • Accompanying pain is common.

  • Progression is slower and fatal outcomes are rare in PPMA.


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