What are the diagnostic criteria for progressive postpolio muscular atrophy (PPMA)?

Updated: Feb 20, 2018
  • Author: Sridharan Ramaratnam, MD, MBBS; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

Criteria for diagnosis

  • Documented history of acute paralytic poliomyelitis with incomplete to nearly complete neurologic and functional recovery

  • Period of neurologic and functional stability lasting at least 15 years

  • New onset of asymmetric weakness and/or atrophy in muscles that were affected previously or were clinically unaffected by polio

  • New onset or worsening of muscle twitching or cramping and pain

  • Electrophysiologic features of acute denervation superimposed on chronic denervation-reinnervation

  • No other medical, neurologic, orthopedic, or psychiatric cause for weakness


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